Strategies towards reducing carbon emission in university campuses: A comprehensive review of both global and local scales

Universities and other Higher Education Institutions (HEIs) have a key role to play in promoting decarbonisation and sustainable development. The implementation of low-carbon and energy-efficient strategies in colleges and University Campuses (UCs) is of utmost importance, as the number of these buildings continues to grow rapidly worldwide. This paper uses an organized search strategy for reviewing the most impactful previous studies regarding decarbonisations strategies in UCs in different climate contexts. This research presents a comprehensive overview of influential parameters, which are practical to be considered in designing new or retrofitting existing UCs which has not been done before and also highlights relevant policies and guidelines required to implement these parameters. These factors are spatial planning and landscape, renewable and clean energy, energy systems, thermal envelope, green transportation, management and control, human-related performance and smartness. This review also explores the recent trends in the decarbonisation of UCs such as the application of smart technologies and implementation of real-time data-based control and management technologies. Finally, this review presents the research gaps, future trends and technologies which will facilitate the decarbonisation of UCs. This review would help researchers and designers to facilitate the transition towards net-zero carbon future in university campuses

A gain-of-function mutation of STAT1: A novel genetic factor contributing to chronic mucocutaneous candidiasis

Heterozygous gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) have increasingly been identified as a genetic cause of autosomal-dominant (AD) chronic mucocutaneous candidiasis (CMC). In this article, we describe a 33-year-old man who experienced chronic refractory candidiasis, recurrent otitis media, and pneumonia resulting in bronchiectasis, severe oral and esophageal candidiases with strictures associated with hypothyroidism and immune hemolytic anemia. His son also suffered from persistent candidiasis, chronic diarrhea, poor weight gain, and pneumonia that resulted in his demise because of sepsis. The immunological workup showed that an inverse CD4/CD8 ratio and serum immunoglobulins were all within normal ranges. The laboratory data revealed failure in response to Candida lymphocyte transformation test. In addition, by Sanger sequencing method, we found a heterozygous mutation, Thr385Met (T385M), located in the DNA-binding domain of STAT1, which was previously shown to be GOF. These findings illustrate the broad and variable clinical phenotype of heterozygous STAT1 GOF mutations. However, more clinical information and phenotype–genotype studies are required to define the clinical phenotype caused by AD STAT1 GOF

Airborne and aerosol pathogen transmission modeling of respiratory events in buildings : An overview of computational fluid dynamics

Publisher Copyright: © 2022 Elsevier LtdPathogen droplets released from respiratory events are the primary means of dispersion and transmission of the recent pandemic of COVID-19. Computational fluid dynamics (CFD) has been widely employed as a fast, reliable, and inexpensive technique to support decision-making and to envisage mitigatory protocols. Nonetheless, the airborne pathogen droplet CFD modeling encounters limitations due to the oversimplification of involved physics and the intensive computational demand. Moreover, uncertainties in the collected clinical data required to simulate airborne and aerosol transport such as droplets’ initial velocities, tempo-spatial profiles, release angle, and size distributions are broadly reported in the literature. There is a noticeable inconsistency around these collected data amongst many reported studies. This study aims to review the capabilities and limitations associated with CFD modeling. Setting the CFD models needs experimental data of respiratory flows such as velocity, particle size, and number distribution. Therefore, this paper briefly reviews the experimental techniques used to measure the characteristics of airborne pathogen droplet transmissions together with their limitations and reported uncertainties. The relevant clinical data related to pathogen transmission needed for postprocessing of CFD data and translating them to safety measures are also reviewed. Eventually, the uncertainty and inconsistency of the existing clinical data available for airborne pathogen CFD analysis are scurtinized to pave a pathway toward future studies ensuing these identified gaps and limitations.Peer reviewe

Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

Predominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and inability to generate effective antibody responses

Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

Background: Predominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and inability to generate effective antibody responses. Objective: We intended to report most common monogenic PADs and to investigate how patients with PAD who were primarily diagnosed as suffering from agammaglobulinemia, hyper-IgM (HIgM) syndrome, and common variable immunodeficiency (CVID) have different clinical and immunological findings. Methods: Stepwise next-generation sequencing and Sanger sequencing were performed for confirmation of the mutations in the patients clinically diagnosed as suffering from agammaglobulinemia, HIgM syndrome, and CVID. Results: Among 550 registered patients, the predominant genetic defects associated with agammaglobulinemia (48 Bruton's tyrosine kinase [BTK] and 6 μ heavy chain deficiencies), HIgM syndrome (21 CD40 ligand and 7 activation-induced cytidine deaminase deficiencies), and CVID (17 lipopolysaccharides-responsive beige-like anchor deficiency and 12 atypical Immunodeficiency, Centromeric instability, and Facial dysmorphism syndromes) were identified. Clinical disease severity was significantly higher in patients with μ heavy chain and CD40 ligand mutations compared with patients with BTK (P = .003) and activation-induced cytidine deaminase (P = .009) mutations. Paralysis following live polio vaccination was considerably higher in patients with μ heavy chain deficiency compared with BTK deficiency (P < .001). We found a genotype-phenotype correlation among patients with BTK mutations regarding clinical manifestation of meningitis and chronic diarrhea. Surprisingly, we noticed that first presentations in most patients with Immunodeficiency, Centromeric instability, and Facial dysmorphism were respiratory complications (P = .008), whereas first presentations in patients with lipopolysaccharides-responsive beige-like anchor deficiency were nonrespiratory complications (P = .008). Conclusions: This study highlights similarities and differences in the clinical and genetic spectrum of the most common PAD-associated gene defects. This comprehensive comparison will facilitate clinical decision making, and improve prognosis and targeted treatment